Argireline, Acetyl Hexapeptide 8

Anti-Aging Peptide Wrinkle-Relaxer Acetyl Hexapeptide-8, formerly called Acetyl Hexapeptide-3.

Reduce the appearance of fine lines and wrinkles while visibly smoothing your complexion with Argireline® Peptide Solution Serum Booster or Acetyl Hexapeptide-8.

$44.95 $34.95
OR
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Argireline is Acetyl Hexapeptide-8, the peptide most associated with the look of expression lines — forehead creases, crow's feet, and the 11s between the brows. Blend it into your base at 2 - 10%.

This is a formulation ingredient, not a finished serum. Do not apply it undiluted.

What is in the bottle

INCI: Water, Acetyl Hexapeptide-8

Two ingredients. That is the whole list.

Clear liquid. Water-soluble. Fragrance-free, paraben-free. 0.5 oz blue glass dropper bottle.

The science: Acetyl Hexapeptide-8 and the SNARE complex

Argireline is a six-amino-acid sequence, first introduced in 2001 and one of the most studied cosmetic peptides in use.

The published research centers on the SNARE complex — the protein assembly that mediates signaling at the neuromuscular junction. Acetyl Hexapeptide-8 has been studied for its interaction with SNARE complex formation, which is why it is grouped with the expression-line peptides rather than the collagen-support ones.

The supplier's efficacy work reports improved appearance of fine lines at a 2% concentration, with measured reductions in wrinkle depth and volume.

These findings are the manufacturer's, from their efficacy dossier, and we reproduce them here under our license agreement. They describe testing of the raw material, not of a finished product you blend at home.

How much to add

Recommended usage rate is 2 to 10%. Using our house rate of 9 drops per 1% per fluid ounce:

Concentration Into 1 oz Into 2 oz
2% 18 drops · 0.6 g 36 drops · 1.2 g
5% 45 drops · 1.5 g 90 drops · 3.0 g
10% 90 drops · 3.0 g 180 drops · 6.0 g

See the serum booster chart for full conversions. Every order includes an instruction guide and chart. 

How to use it

  1. Choose a water-based serum, gel, lotion, or cream. Hyaluronic acid serum is the usual base.
  2. Add the drops for the percentage you want.
  3. Cap and shake well.
  4. Refrigerate what you are not using.
  5. Apply the finished blend morning and night to the forehead, around the eyes, and the lip area.

What it is for

Argireline is formulated for the lines that come from movement rather than sun or slack — the ones that deepen because your face makes the same shapes every day.

  • Forehead creases
  • The 11s between the brows
  • Crow's feet at the outer corners of the eyes
  • Fine lines around the mouth

For firmness across the whole face rather than specific lines, Matrixyl 3000 is the one to reach for instead. They layer well together.

Why buy it raw

Finished products naming this ingredient rarely tell you how much is in them, and it is usually less than you would choose. Blend it yourself and the number is yours — because you counted the drops in.

One 0.5 oz bottle blends several ounces of finished serum, depending on the percentage you pick.

Blending with other peptides

Argireline layers with Snap-8, Syn-Ake, and Inyline. Each works on the look of expression lines through a different route, so combining them doesn't double up on the same thing. Keep the combined total sensible — the base still has to be mostly base.

Prefer liposomal delivery and a lower use rate? See Argireline Amplified.

Storage

Refrigerate on arrival. The blue glass keeps light out.

For external use only. Cosmetic grade. Do not apply undiluted to skin. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Argireline is a registered trademark of Lipotec S.A.U., used under license.

EWG Score

The Skin Deep® ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. Learn how EWG Skin Deep scores work →
1-2 Low Hazard
3-6 Moderate Hazard
7-10 High Hazard

  • Water Origin:
  • Acetyl Hexapeptide-8 Origin:
  • Caprylyl Glycol Origin:

What is Argireline?
Argireline is the most trusted anti-aging peptide. It is one of the most popular, widely used, and reputable anti-wrinkle peptides used in the skincare industry.
Is Argireline a good alternative to botox?
Argireline is considered one of the best botox alternatives! Argireline relaxes your expression line facial muscles whereas Botox paralyzes those muscles. Both result in a reduction of fine lines and wrinkles.
Does this product need to be refrigerated?
We recommend placing Argireline in your fridge to keep it fresh for the next time you need it.

INCI: Water (and) Acetyl Hexapeptide-8

Recommended Usage Rate: 2-10%

Place in the refrigerator upon arrival.

Color: Colorless

Appearance: Clear liquid

Solubility: Water-soluble

pH: 3.0-6.0

Scent: No fragrance, unscented

Storage: Refrigerate

Shelf-life: 12 months after opening

Country of Origin: Spain

Raw Material: Plant-based

Animal Testing: Cruelty-free

GMO: Non-GMO

Vegan: Yes

CAS: 616204-22-9

HS Code: 3504.00

Acetyl Hexapeptide-8 is a peptide that targets the formation of wrinkles by reducing contractions. It also helps reduce the appearance and depth of expression lines.

We recommend a 2-10% concentration when mixing the Argireline® Peptide Solution into any existing skincare product or adding it to your recipe at home. With your current product, blend the Argireline® Peptide Solution into the product until you have a uniform mixture.

If you're creating a lotion, serum, or moisturizer at home, be sure to add your Serum Booster drops during the water phase.

For a 10% concentration of Argireline in a 1-ounce skincare product, bulk base, or formula, add 90 drops.

For a 2% concentration of Argireline in a 2-ounce skincare product, bulk base, or formula, add 36 drops.

Included is our product instruction guide on how to add serum boosters to your formula. Argireline® Peptide Solution works excellent with other anti-wrinkle peptides. For example, Snap-8™ Peptide, Inyline® Peptide, and Syn®-Ake are great candidates. Using a blend of peptides can maximize their skincare benefits.

Formulation: Add transparent liquid at the end of the formulation. You can also add it to the water phase. This peptide is super easy to incorporate. It is a clear liquid that has the consistency of water. It is fragrance-free and will not change the product scent.

When used at high concentrations, as with all ingredients, the formula you are adding it to may get thinner.

Size: .5 ounce of Argireline® Peptide Solution NP (non-paraben), protected from light by a blue glass bottle with a dropper.

Place in the refrigerator upon arrival.

Argireline® Peptide Solution is an anti-wrinkle active used in serum making. Do not apply directly to the skin.

Sample Recipes

If you're not sure how to add a serum booster to one of your favorite skincare products, you might be nervous about trying it for the first time. We're here for you! We've made a helpful video to walk you, step-by-step, through the process of adding a serum booster to an existing product.

Are you feeling adventurous? Making skincare products is fun and a lot easier than you might think! Check out our recipe for a supercharged anti-aging serum with an Argireline boost or how to make your own Argireline Peptide face cream.

Applications:

  • Anti-Aging Day and Night Moisturizers
  • Anti-Aging Face Serums
  • Body Butters
  • Eye Creams and Gels
  • Facial Mists, Toners, or Astringents
  • Highly Concentrated Back Bar Facial Treatments
  • Hyaluronic Facial Serums
  • Lotions and more!

MSDS Sheet

Lipotec Active Ingredients

850061380104

Do not directly apply to your skin. Instead, this product should be added to a formulation at the recommended usage rate.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated the statements contained herein. This product is not intended to diagnose, treat, cure, or prevent disease. Always consult with your professional skincare provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

Argireline® Peptide Solution is a registered trademark of Lipotec S.A. or its affiliates.

Intro music

Slide 1:
Anti-Aging Solutions
Rejuvenate with Youth-Boosting Argireline® Peptide

Slide 2:
Video of what it is.
Boost any skincare product's effectiveness. Simply add 90 drops of Argireline® Peptide to a 1-ounce base, custom formula or existing product for a 10% concentration.

Slide 3:
Highest Quality Anti-Aging Peptides for Making Skincare
Reduce the appearance of fine lines and wrinkles and visibly smooth your complexion.

Slide 4:
Benefits of Argireline® Peptide -
Anti-aging
Anti-wrinkle
Expression lines
Fine lines and wrinkles

Slide 5:
Skin Perfection Logo
Supercharge your skin with the highest quality anti-aging peptides.

Outro music

INGREDIENTS MATTER.

Discover the anti-aging ingredient for wrinkles that I swear by.
Acetyl Hexapeptide-8

Anti-Aging Peptides For Lotion Making

Customer Reviews

Questions & Answers

Have a Question?

We answer by email, and helpful questions may be added to this page.

QCan Argireline Acetyl Hexapeptide 8 be used alone prior to putting on niacinamide & hyaluronic serum?
A
Argireline is an anti-aging ingredient and needs to be mixed prior to use. You can add it to your Niacinamide and Hyaluronic Acid Serum to give it a boost.
QCan this be mixed with just filtered water? I would make only 4-5 days of Argireline-water solution at a time and keep in the fridge to prevent any microbial issues. Also, how long should Argireline ideally be allowed to sit and absorb into skin before applying other products (such as sunscreen) on top?
A

Yes, you can use Argireline Peptide with water.

You can apply additional products, including sunscreen, as soon as the Argireline solution is dry.

QCan I just use pretty much all of the serums together to get all effects, or do some not go with others?
A
Yes, you can combine multiple Serum Boosters together. There is no right or wrong number. Just make sure that you are not using Copper Peptide with Vitamin C.
QWhat would be similar to this (natural botox like effect) that can be used in a serum that is completely made with oils and no water?
A

Unfortunately, there are none. Peptides are "hydrophilic" or water-loving. Your best bet is to use an emulsifier to incorporate the peptides or add to a base of Hyaluronic Acid.

You can find some plant extracts that are oil-soluble however, they will have water in them and an emulsifier.

QI make a facial moisturizer. It is lotion/moisturizer consistency. The only two ingredients are tallow (rendered beef fat) and jojoba oil. Since this is moisturizer consistency can it be mixed in? It would be able to be uniformly mixed.
A
Yes, the Argireline Peptide Serum Booster can be added to your moisturizer! We recommend using a 10% concentration at the end of formulation.
QCan I use Argireline with Vitamin C?
A
Argireline Peptide is compatible with many different ingredients including Vitamin C.
QDo you ship to Australia?
A
Yes! We ship worldwide including Australia.

Shipping quotes are given at checkout.

Please view our shipping guide for the latest information about any country shipping delays and order minimums.

All international orders may have additional duties, taxes, customs, or other fees associated with purchase. These taxes are the customer's responsibility.
QHow does this compare to the Ordinary 10% Argireline Solution?
A
The Argireline Peptide Serum Booster needs to be added to any skincare product, base, or formulation.

You can easily create a clean beauty product by adding a 10% concentration (the same that the Ordinary Solution uses) to a base of Hyaluronic Acid. You will make a formula that has the same 10% concentration as the Ordinary but without additional chemical additives or preservatives such as Phenoxyethanol.
QI am making a DIY serum. What other ingredients should I use with Argireline?
A
Ask your self what your goals are. If you are looking to reduce the appearance of wrinkles and want to make a DIY powerhouse serum, add Snap-8, Inyline, and Syn-Ake. If you want to firm a sagging jawline, add Uplevity, Pepha Tight, and Relistase. For more volume and supple skin, consider Hyaluronic Acid and Syn-Coll. You can also check out our peptide guide at https://nituralorganicskincare.com/anti-aging-peptides/ to help locate the best peptides to use.
QIs this the same as Acetyl Hexapeptide 3?
A
Acetyl Hexapeptide-3 is an old INCI name. Argireline now is called Acetyl Hexapeptide-8.
QCan I add Argireline to Jojoba oil?
A
Argireline is a water-based anti-aging peptide. It can be added to our Ultra Hyaluronic Acid or another serum base. It should not be added to an oil-based product as water can't combine with oil unless an emulsifier is used.
QHow do I add this to a 1.7 ounce moisturizer?
A
For a 10% concentration added to a 1-ounce of a base, you would need to add 1 1/2 teaspoons plus 11 drops.

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