{"title":"Matrixyl 3000","description":"\u003cp\u003e\u003cstrong\u003eMatrixyl 3000 is an amino acid complex built from two sequences — palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 — carried in a glycerin and water gel. Cosmetic formulators use it at 3 to 8 percent to help skin look firmer and to soften the look of fine lines. It is water-soluble and blends into most serum bases.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eThat paragraph is the whole answer. Everything below is the detail almost nobody publishes: the full ingredient list, the exact usage rate, and exactly how much to add to a base you are holding.\u003c\/p\u003e\n\n\u003ch2\u003eFast facts\u003c\/h2\u003e\n\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eINCI\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eGlycerin, Aqua (Water), Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eFormer INCI\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePalmitoyl Oligopeptide — renamed Palmitoyl Tripeptide-1 in 2016\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDeveloped by\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSederma\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eUsage rate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e3 to 8 percent\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eAppearance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eOpaque gel\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSolubility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eWater-soluble\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBlends with\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHyaluronic acid, vitamin C, niacinamide, copper peptide, Argireline, Matrixyl Synthe-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eShelf life\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e8 months from opening, refrigerated\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eOur bottle\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e0.5 oz (15 ml) blue glass dropper\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003ch2\u003eWhat Matrixyl 3000 actually is\u003c\/h2\u003e\n\n\u003cp\u003eTwo amino acid sequences, working on different signals.\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePalmitoyl Tripeptide-1\u003c\/strong\u003e (pal-GHK) — the sequence most often associated with the look of firmer, better-supported skin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePalmitoyl Tetrapeptide-7\u003c\/strong\u003e (pal-GQPR) — the sequence associated with skin that looks calmer and more even.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eSederma describes both as matrikines: messenger sequences that communicate with skin cells. The palmitoyl part is a fatty acid attached to each one so the sequence can travel through the skin's outer layer instead of sitting on top of it.\u003c\/p\u003e\n\n\u003cp\u003eThe original Matrixyl, released in 1999, was a single sequence — palmitoyl pentapeptide-4. Matrixyl 3000 is the two-sequence version that replaced it.\u003c\/p\u003e\n\n\u003cp\u003eHere is the part worth understanding: \u003cstrong\u003ethe 3 to 8 percent figure refers to the whole gel, not the amino acids alone.\u003c\/strong\u003e Most of what is in the bottle is glycerin and water. That is normal and it is how the raw material is supplied — peptides work at very low concentrations. Any brand quoting a percentage is quoting the complex.\u003c\/p\u003e\n\n\u003ch2\u003eHow much to use\u003c\/h2\u003e\n\n\u003cp\u003eThis is the question we get more than any other, so here is the full answer rather than a vague one.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eWeigh it.\u003c\/strong\u003e A drop is not a fixed amount — its size changes with how thick the liquid is, the shape of the dropper, and the temperature. Matrixyl 3000 is a thick gel, so it drops considerably larger than a thin peptide solution. Percentages and grams are exact, and a small digital scale removes all the guesswork.\u003c\/p\u003e\n\n\u003cp\u003eA 1 ounce base weighs about 30 grams. A 2 ounce base weighs about 60 grams.\u003c\/p\u003e\n\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eConcentration\u003c\/th\u003e\n\u003cth\u003eInto 1 oz (30 g)\u003c\/th\u003e\n\u003cth\u003eInto 2 oz (60 g)\u003c\/th\u003e\n\u003cth\u003eNotes\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003e3%\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e0.9 g — 0.89 ml\u003c\/td\u003e\n\u003ctd\u003e1.8 g — 1.77 ml\u003c\/td\u003e\n\u003ctd\u003eEntry level. Where most finished products sit.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003e5%\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e1.5 g — 1.48 ml\u003c\/td\u003e\n\u003ctd\u003e3.0 g — 2.96 ml\u003c\/td\u003e\n\u003ctd\u003eMid-range. A good default.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003e8%\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e2.4 g — 2.37 ml\u003c\/td\u003e\n\u003ctd\u003e4.8 g — 4.73 ml\u003c\/td\u003e\n\u003ctd\u003eTop of the recommended range.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003cp\u003e\u003cstrong\u003eThe formula:\u003c\/strong\u003e base weight in grams × percentage ÷ 100 = grams of active. So 8% into a 1 ounce base is 30 × 8 ÷ 100 = 2.4 grams.\u003c\/p\u003e\n\n\u003cp\u003eGoing above 8 percent does not give you more. You are mostly adding glycerin and water to your base at that point, and thinning everything else in the formula.\u003c\/p\u003e\n\n\u003cp\u003eWorking in drops instead? See the \u003ca href=\"\/pages\/product-instructions-for-serum-boosters\"\u003eserum booster conversion chart\u003c\/a\u003e for approximate drop counts and the rates for every other active we sell.\u003c\/p\u003e\n\n\u003ch2\u003eMatrixyl 3000 compared to the peptides people ask about next\u003c\/h2\u003e\n\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003ePeptide\u003c\/th\u003e\n\u003cth\u003eINCI\u003c\/th\u003e\n\u003cth\u003eWhat it is for\u003c\/th\u003e\n\u003cth\u003eUsage rate\u003c\/th\u003e\n\u003cth\u003eLayer with Matrixyl 3000?\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMatrixyl 3000\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePalmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7\u003c\/td\u003e\n\u003ctd\u003eThe look of overall firmness across the face\u003c\/td\u003e\n\u003ctd\u003e3–8%\u003c\/td\u003e\n\u003ctd\u003e—\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eMatrixyl Synthe-6\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePalmitoyl Tripeptide-38\u003c\/td\u003e\n\u003ctd\u003eThe look of filled-in wrinkles, targeted\u003c\/td\u003e\n\u003ctd\u003e2%\u003c\/td\u003e\n\u003ctd\u003eYes. Different jobs, no conflict.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eArgireline\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eAcetyl Hexapeptide-8\u003c\/td\u003e\n\u003ctd\u003eThe look of softened expression lines\u003c\/td\u003e\n\u003ctd\u003e2–10%\u003c\/td\u003e\n\u003ctd\u003eYes.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSyn-Coll\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePalmitoyl Tripeptide-5\u003c\/td\u003e\n\u003ctd\u003eThe look of firmness, a different signal route\u003c\/td\u003e\n\u003ctd\u003e1–3%\u003c\/td\u003e\n\u003ctd\u003eYes.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eGHK-Cu\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCopper Tripeptide-1\u003c\/td\u003e\n\u003ctd\u003eThe look of overall skin quality and tone\u003c\/td\u003e\n\u003ctd\u003e0.3–3%\u003c\/td\u003e\n\u003ctd\u003eYes.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003cp\u003eIf you only pick one, pick Matrixyl 3000. It is the broadest of the group and the easiest to formulate around. \u003ca href=\"\/products\/matrixyl-synthe-6-wrinkle-firming-filler\"\u003eMatrixyl Synthe-6\u003c\/a\u003e is the one to add second if your concern is a specific line rather than overall firmness.\u003c\/p\u003e\n\n\u003ch2\u003eTwo ways to use it\u003c\/h2\u003e\n\n\u003ch3\u003eBlend it yourself\u003c\/h3\u003e\n\n\u003cp\u003eThe \u003ca href=\"\/products\/matrixyl-3000\"\u003eMatrixyl 3000 Serum Booster\u003c\/a\u003e is the raw material at full strength. You choose the percentage and you choose the base.\u003c\/p\u003e\n\n\u003col\u003e\n\u003cli\u003ePick your base. \u003ca href=\"\/products\/hyaluronic-acid-serum\"\u003eHyaluronic acid serum\u003c\/a\u003e is the usual choice — it is water-based, so the two mix cleanly, and it carries well.\u003c\/li\u003e\n\u003cli\u003eWeigh in the amount from the table above.\u003c\/li\u003e\n\u003cli\u003eCap it and shake well.\u003c\/li\u003e\n\u003cli\u003eRefrigerate what you are not using. The blue glass keeps light out; the cold keeps the blend stable.\u003c\/li\u003e\n\u003cli\u003eApply to a clean, dry face and neck, morning and night. Moisturiser over the top. Sunscreen in the morning.\u003c\/li\u003e\n\u003c\/ol\u003e\n\n\u003cp\u003eDo not apply the booster undiluted. It is a formulation ingredient, not a finished serum.\u003c\/p\u003e\n\n\u003ch3\u003eOr skip the mixing\u003c\/h3\u003e\n\n\u003cp\u003eThe \u003ca href=\"\/products\/matrixyl-collagen-booster-serum\"\u003e20% Matrixyl Collagen Serum\u003c\/a\u003e is already blended and ready to use. The name is the disclosure: 20 percent of the finished serum is Matrixyl 3000 complex. We put the number on the label because you should not have to guess.\u003c\/p\u003e\n\n\u003ch2\u003eQuestions we actually get asked\u003c\/h2\u003e\n\n\u003cp\u003e\u003cstrong\u003eHow much Matrixyl 3000 for an 8% blend in 1 ounce?\u003c\/strong\u003e\u003cbr\u003e\n2.4 grams, which is 2.37 ml. At 5 percent, 1.5 grams. At 3 percent, 0.9 grams.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eWhy do you recommend weighing instead of counting drops?\u003c\/strong\u003e\u003cbr\u003e\nBecause a drop is not a fixed amount. Matrixyl 3000 is a thick gel and forms a much bigger drop than a thin peptide solution, so the same drop count gives a different concentration depending on the product. Weight does not have that problem.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCan I use it with retinol?\u003c\/strong\u003e\u003cbr\u003e\nYes. Many people prefer Matrixyl 3000 in the morning and retinol at night, simply because retinol can be drying and splitting them up is gentler on the skin.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCan I add it to a vitamin C serum?\u003c\/strong\u003e\u003cbr\u003e\nYes. Both Matrixyl 3000 and Matrixyl Synthe-6 blend into a vitamin C serum without trouble.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCan I use it with copper peptide?\u003c\/strong\u003e\u003cbr\u003e\nYes. They are compatible. Note that copper peptide itself should not be combined with vitamin C.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCan I use it with Argireline?\u003c\/strong\u003e\u003cbr\u003e\nYes. Argireline works on the look of expression lines and Matrixyl 3000 on overall firmness, so they layer well.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCan I add it to my facial oil blend?\u003c\/strong\u003e\u003cbr\u003e\nNo. Matrixyl 3000 is water-soluble, so it will not incorporate into jojoba, argan, coconut, or rosehip. Use a water-based serum or gel as your base instead.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCan I use both Matrixyls together?\u003c\/strong\u003e\u003cbr\u003e\nYes. Matrixyl 3000 for the look of firmness across the whole face, Matrixyl Synthe-6 on the specific lines. Apply two minutes apart so each one absorbs.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eCan I use it with a derma roller?\u003c\/strong\u003e\u003cbr\u003e\nBlend it into a hyaluronic acid base first. Never apply the undiluted booster.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHow long before I see a difference?\u003c\/strong\u003e\u003cbr\u003e\nSederma's efficacy work reports visible change in the look of wrinkle depth and skin suppleness over two months of twice-daily use. Most people notice the look of hydration and plumpness earlier than they notice the look of lines.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHow long does it keep?\u003c\/strong\u003e\u003cbr\u003e\n8 months from opening. The label carries an open-jar symbol with an 8 in it. Refrigerate on arrival.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eDoes it suit sensitive skin?\u003c\/strong\u003e\u003cbr\u003e\nIt is generally well tolerated and it is fragrance-free and paraben-free. As with any new active, patch test first. If you are pregnant, nursing, or under a dermatologist's care, ask your own provider before adding anything new.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eDo I need to keep using it?\u003c\/strong\u003e\u003cbr\u003e\nYes. The visible benefits depend on continued use, the same as any cosmetic active.\u003c\/p\u003e\n\n\u003ch2\u003eA note from the bench\u003c\/h2\u003e\n\n\u003cp\u003eI have been formulating with Matrixyl 3000 for most of the twenty years I have been a cosmetic formulator, and the thing that still bothers me is how hard it is to find out how much of it is in anything.\u003c\/p\u003e\n\n\u003cp\u003eWalk down any shelf. You will find dozens of products naming this ingredient. Almost none of them will tell you the concentration. \"Proprietary blend\" does a lot of work in this industry, and what it usually means is that the number would disappoint you.\u003c\/p\u003e\n\n\u003cp\u003eSo we publish ours. The percentage is on the label, the ingredient list is printed in full with real INCI names, and the arithmetic is on this page so you can check it. If you are going to put something on your face twice a day, you are entitled to know what is in it and how much.\u003c\/p\u003e\n\n\u003cp\u003eThat is the whole reason this page exists.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003e— Kari Thomas, Founder and Cosmetic Formulator, Skin Perfection. Certificate of Natural Preservation. Author of \u003c\/em\u003e5-Minute Anti-Aging Formulas\u003cem\u003e.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eThis page has been reviewed by \u003ca href=\"\/pages\/about\"\u003eDr. Jen Haley, a board-certified dermatologist\u003c\/a\u003e.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\n\u003cul\u003e\n\u003cli\u003eSederma (Croda). \u003cem\u003eMatrixyl 3000 Efficacy Dossier\u003c\/em\u003e, 2005.\u003c\/li\u003e\n\u003cli\u003eMaquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. \"Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine.\" \u003cem\u003eFEBS Letters\u003c\/em\u003e, 1988; 238(2): 343–346.\u003c\/li\u003e\n\u003cli\u003eKatayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. \"A pentapeptide from type I procollagen promotes extracellular matrix production.\" \u003cem\u003eJournal of Biological Chemistry\u003c\/em\u003e, 1993; 268(14): 9941–9944.\u003c\/li\u003e\n\u003cli\u003eSchagen SK. \"Topical Peptide Treatments with Effective Anti-Aging Results.\" \u003cem\u003eCosmetics\u003c\/em\u003e, 2017; 4(2): 16.\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.ewg.org\/skindeep\/\" rel=\"noopener\" target=\"_blank\"\u003eEWG Skin Deep ingredient database\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cem\u003eCosmetic use only. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003ch2\u003eShop Matrixyl 3000\u003c\/h2\u003e\n\n\u003cp\u003e\u003ca href=\"\/products\/matrixyl-3000\"\u003eMatrixyl 3000 Serum Booster\u003c\/a\u003e to blend yourself, or the \u003ca href=\"\/products\/matrixyl-collagen-booster-serum\"\u003e20% Matrixyl Collagen Serum\u003c\/a\u003e ready to use. More options in \u003ca href=\"\/collections\/serum-boosters\"\u003eSerum Boosters\u003c\/a\u003e and \u003ca href=\"\/collections\/anti-aging-peptides\"\u003eAnti-Aging Peptides\u003c\/a\u003e.\u003c\/p\u003e","products":[{"product_id":"peptide-cocktail-anti-aging-serum","title":"Super Peptide Anti-Aging Serum","description":"\u003ch2\u003eSuper Peptide Anti Aging Serum - Formerly the Peptide Cocktail \u003c\/h2\u003e\n\u003cp\u003eOur Supercharged Super Peptide Anti-Aging Serum is the ultimate anti-aging serum formulated with 99% peptides! The Super Peptide Anti-Aging Serum delivers 8 age-fighting peptides, clinically validated to reduce the signs of aging and restore your skin's optimal appearance.\u003c\/p\u003e\n\u003cp\u003eWhat's the result? You will see a reduced appearance of wrinkles, improved skin tone and texture, and plumper, suppler, and lifted skin. All in just one week.\u003c\/p\u003e\n\u003cp\u003eThree of the best wrinkle-reducing peptides: Argireline Peptide Solution, Leuphasyl, and Snap 8, target and relax overused facial muscles that contribute to the appearance of aging. Additionally, Aldenine and Melanostatine 5 combat the effects of hyperpigmentation and help fade age spots. \u003cbr\u003e\u003cbr\u003eMatrixyl 3000 and Syn-Coll replenish the skin's appearance by increasing your skin's natural fullness for a youthful complexion.\u003c\/p\u003e\n\u003cp\u003ePentamide-6 helps improve the skin's elasticity, giving it a visibly lifted, more youthful appearance.\u003c\/p\u003e\n\u003cp\u003eYour skin will appear visibly smoother, firmer, and significantly younger. Our supercharged Super Peptide Anti-Aging Serum is suitable for all skin types and is a great alternative to wrinkle injections.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBenefits:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e8 Supercharged anti-aging ingredients\u003c\/li\u003e\n\u003cli\u003eReduces the appearance of wrinkles\u003c\/li\u003e\n\u003cli\u003eVisibly lifts and firms\u003c\/li\u003e\n\u003cli\u003eIncreases your complexion and youthful appearance\u003c\/li\u003e\n\u003cli\u003eBrightens and improves skin clarity while evening skin tone\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eKey Ingredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e5% Aldenine®\u003c\/li\u003e\n\u003cli\u003e10% Argireline® Peptide Solution\u003c\/li\u003e\n\u003cli\u003e10% Leuphasyl®\u003c\/li\u003e\n\u003cli\u003e20% Matrixyl™ 3000\u003c\/li\u003e\n\u003cli\u003e5% Melanostatine® 5\u003c\/li\u003e\n\u003cli\u003e10% Snap-8™\u003c\/li\u003e\n\u003cli\u003e15% Syn®-Coll\u003c\/li\u003e\n\u003cli\u003e24% Peptamide™ 6\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eParaben-Free + No Added Fragrance\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSkin Types: \u003c\/strong\u003eFor all.\u003c\/p\u003e","brand":"Skin Perfection","offers":[{"title":"1 oz. airless bottle","offer_id":37392693723301,"sku":"SPO-Peptide-Cocktail-1oz","price":149.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0069\/7719\/1993\/files\/peptide-cocktail-multi-peptide-anti-aging-serum.jpg?v=1762819316"},{"product_id":"uplift-eye-cream","title":"Uplift Eye Cream","description":"\u003ch2\u003eUplift Eye Cream\u003c\/h2\u003e\n\u003cp\u003eAll-in-one anti-aging eye cream with innovative age-defying peptides to lift, firm, and brighten.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003cspan style=\"color: #99cc00;\"\u003eParaben-Free + Sulfate-Free\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe eyes are said to be the windows to the soul and often become the first place to show the signs of aging. Uplift is an all-around eye cream that firms, lifts, and tightens the delicate eye area.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDiminish the Look of Crow's Feet\u003c\/li\u003e\n\u003cli\u003eReduce Puffiness with Natural Proteins\u003c\/li\u003e\n\u003cli\u003eTreat Dark Circles with Haloxyl\u003c\/li\u003e\n\u003cli\u003eFade Discolorations\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eUplift is incredibly moisturizing and helps to restore hydration.\u003c\/p\u003e\n\u003cp\u003eWith over 48% peptides (oh, yeah!), your eyes will be lifted, the look of crow's feet will diminish, and sagging eyelids will become a thing of the past. Instead, your eyes will appear brighter and more youthful-looking.\u003c\/p\u003e\n\u003ch2\u003eBenefits of Eye Creams and Key Ingredients:\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eArgireline® Peptide and Snap-8™: \u003c\/strong\u003eare strands of amino acids that diminish the look of wrinkles by relaxing the appearance of expression lines, resulting in less noticeable wrinkles.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMatrixyl\u003cstrong\u003e®\u003c\/strong\u003e 3000\u003c\/strong\u003e:\u003cstrong\u003e \u003c\/strong\u003ecan take 5 to 10 years off of your appearance and keep you looking youthful.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePepha\u003cstrong\u003e®\u003c\/strong\u003e Tight\u003c\/strong\u003e:\u003cstrong\u003e \u003c\/strong\u003etargets droopy eyelids, firming and tightening.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegu\u003cstrong\u003e®\u003c\/strong\u003e-Age\u003c\/strong\u003e:\u003cstrong\u003e \u003c\/strong\u003esoy and rice protein reduce puffiness under the eyes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlpha Arbutin and Licorice Root:\u003c\/strong\u003e All-natural skin lighteners help to fade under-eye discolorations.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHaloxyl\u003c\/strong\u003e\u003cstrong\u003e®:\u003c\/strong\u003e\u003cstrong\u003e \u003c\/strong\u003efades the appearance of dark circles by releasing excess under-eye fluid build-up.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCopper Peptides:\u003c\/strong\u003e\u003cstrong\u003e \u003c\/strong\u003erenew the skin's surface with regenerating natural peptides\u003cstrong\u003e.\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhytocell Tec Malus Domestica: \u003c\/strong\u003estem cells that promote a more youthful appearance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSyn\u003cstrong\u003e®\u003c\/strong\u003e-Coll:\u003c\/strong\u003e\u003cstrong\u003e \u003c\/strong\u003evisibly helps the skin regenerate its appearance and look significantly younger.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpin Trap:\u003c\/strong\u003e \u003cstrong\u003e- \u003c\/strong\u003ehalt the effects of free radicals with one of the most potent antioxidants.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTarget wrinkles with Argireline® Peptide, Snap-8™, Phytocell™ Tec. 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Patch test first if your skin is reactive.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e20% Matrixyl 3000 clinical-strength peptide concentration to support collagen pathways\u003c\/li\u003e\n\u003cli\u003ePepha Tight marine complex plus DMAE for immediate tightening and improved texture\u003c\/li\u003e\n\u003cli\u003eIncludes hyaluronic acid and vitamin E for measurable hydration and antioxidant support\u003c\/li\u003e\n\u003cli\u003eParaben-free, cruelty-free formula made in the USA, suitable for most skin types except sensitive\u003c\/li\u003e\n\u003cli\u003eCompatible with DIY serum boosters and professional layering routines\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eUnlike many diluted department-store serums, this product delivers a disclosed 20% Matrixyl concentration for a clinical-strength approach. Use in the morning or at night after cleansing, before heavier creams or oils. Designed for non-sensitive skin and for users who want transparent ingredient concentrations you can trust. Formulated and made in the USA with full ingredient disclosure. 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For targeted frown lines, apply a thin layer to the glabellar area and track improvement over 30 days.\u003c\/p\u003e\u003cp\u003eFormulated with clinically studied peptide ingredients and hyaluronic acid, and manufactured in the USA. Learn more today about proper application and pairing with your existing routine.\u003c\/p\u003e","brand":"Skin Perfection","offers":[{"title":"0.50 oz airless bottle","offer_id":37392491905189,"sku":"SPO-ExpressionLineSerum-.5oz","price":46.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0069\/7719\/1993\/files\/expression-line-deep-wrinkle-serum.jpg?v=1762819235"},{"product_id":"eye-bright-with-argireline","title":"Eye Bright Argireline Cream","description":"\u003cp\u003eEye Bright Anti-Aging Eye Cream is an anti-aging peptide formula designed to reduce the appearance of crow's feet and dark circles while firming the eyelid area. It combines quantified peptide actives and plant-derived antioxidants to refresh your eye contour without caffeine.\u003c\/p\u003e\u003cp\u003eIf you struggle with under-eye puffiness, dark circles, or loss of firmness, this cream targets those concerns directly. The formula uses a specific peptide complex to signal collagen support while botanical extracts reduce discoloration and fluid retention.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e25% Argireline to help minimize fine lines and expression wrinkles\u003c\/li\u003e\n\u003cli\u003e15% Matrixyl 3000 to support collagen signaling for firmer skin\u003c\/li\u003e\n\u003cli\u003e8% Pepha Tight for visible tightening and immediate lift sensations\u003c\/li\u003e\n\u003cli\u003eHaloxyl plus licorice extract to diminish dark circles and discoloration\u003c\/li\u003e\n\u003cli\u003eCaffeine-free formula with American ginseng to reduce puffiness via circulation\u003c\/li\u003e\n\u003cli\u003eParaben-free, cruelty-free, and made in the USA with plant-derived antioxidants\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eUse daily after cleansing and before moisturizer to target lines and puffiness. Unlike caffeine-based eye gels, this cream is caffeine-free while still addressing fluid retention and circulation. Compared to generic eye creams, this product lists peptide concentrations and targeted actives for clearer comparison.\u003c\/p\u003e\u003cp\u003eFormulated with measurable peptide percentages and in accordance with standard cosmetic safety practices, this cream is paraben-free, cruelty-free, and produced in the USA. 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In that case, this serum combines peptide actives and retinol to tighten, lift, fade hyperpigmentation, increase cell turnover, and deliver antioxidants.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eContains 25% Argireline peptide to reduce the appearance of dynamic fine lines\u003c\/li\u003e\n\u003cli\u003eFeatures 15% Matrixyl 3000 Palmitoyl Tripeptide 5 to support collagen and elastin synthesis\u003c\/li\u003e\n\u003cli\u003eIncludes Retinol (Vitamin A) to increase cell turnover and improve skin tone, suitable for those not sensitive to retinol\u003c\/li\u003e\n\u003cli\u003ePepha-Tight algae-derived tightener plus Alpha Lipoic Acid for improved surface texture and glow.\u003c\/li\u003e\n\u003cli\u003eParaben-free, cruelty-free formula manufactured in the USA with clinically validated peptides\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eUnlike single-ingredient retinol serums, Liquid Facelift pairs multiple clinically researched peptides with antioxidants and tighteners, providing multi-mechanism support for firmness and tone. 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Compared to single-peptide products, Peptide Fusion uses a multi-target peptide strategy to address collagen formation, wrinkle smoothing, and hydration in a single step.\u003c\/p\u003e\u003cp\u003eFormulation stability and safety tested in our labs; recommended by our clinical formulators for mature complexions seeking professional-strength peptide concentrations. 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It combines 11 clinically validated peptides, including Argireline Snap-8 and Matrixyl 3000, to address vertical lines, the 11s forehead lines, and upper lip creases.\u003c\/p\u003e\u003cp\u003eIf you struggle with persistent expression wrinkles or loss of firmness, this serum helps by delivering multiple actives that relax muscle-related lines and stimulate matrix support. 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The formula combines topical collagen-stimulating Syn-Coll with peptide tighteners and moisture-binding hyaluronic acid to improve facial elasticity and surface texture.\u003c\/p\u003e\u003cp\u003eIf you struggle with crepey skin, marionette lines, or loss of cheek and jawline support, this serum is formulated to help: 5% Syn-Coll targets collagen dynamics, while Relistase enhances tissue tightening, and hyaluronic acid restores immediate hydration and volume.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e5% Syn-Coll (topical collagen booster) to target marionette lines\u003c\/li\u003e\n\u003cli\u003e20% Relistase peptide concentrate to support visible tightening\u003c\/li\u003e\n\u003cli\u003eHyaluronic acid for moisture retention and immediate plumping\u003c\/li\u003e\n\u003cli\u003eIncludes Matrixyl 3000 and Regu-Age (teprenone) for improved tone\u003c\/li\u003e\n\u003cli\u003eSpin Trap antioxidant and Homeostatine to defend against environmental stressors\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eCompared to injectables, this topical treatment is noninvasive and designed to build firmness over time. Unlike diluted department-store serums, this formula lists active concentrations and avoids fillers and parabens, so you see which actives you are applying.\u003c\/p\u003e\u003cp\u003eSuitable for all skin types, including dry mature skin, the serum is made in the USA, paraben-free, and cruelty-free. Formulated with clinically studied peptides such as Matrixyl 3000 and Syn-Coll, the product is stability tested and recommended for anyone seeking measurable peptide-driven firming without injections.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBenefits:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eBoosts your complexion with peptides\u003c\/li\u003e\n\u003cli\u003eSkin firming treatment\u003c\/li\u003e\n\u003cli\u003eImproves facial elasticity\u003c\/li\u003e\n\u003cli\u003eSuper antioxidants for healthy skin\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eKey Ingredients:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eMatrixyl® 3000 (Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7)\u003c\/li\u003e\n\u003cli\u003eRelistase\u003c\/li\u003e\n\u003cli\u003eRegu®-Age\u003c\/li\u003e\n\u003cli\u003eSyn®-Coll\u003c\/li\u003e\n\u003cli\u003eTeprenone\u003c\/li\u003e\n\u003cli\u003eHyaluronic Acid\u003c\/li\u003e\n\u003cli\u003eSpin Trap PBN\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSkin types: \u003c\/strong\u003eAll.\u003c\/p\u003e\u003cp\u003eHyaluronic Acid, Relistase, Matrixyl® 3000, Regu®-Age, Syn®-Coll, Teprenone, Homeostatine, Spin Trap PBN, Leuconostoc\/Radish Root Ferment Filtrate.\u003c\/p\u003e","brand":"Skin Perfection","offers":[{"title":"0.50 oz airless bottle","offer_id":37393187799205,"sku":"SPO-YouthSerum-.5oz","price":38.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0069\/7719\/1993\/files\/youth-serum.jpg?v=1762819142"},{"product_id":"matrixyl-3000","title":"Matrixyl 3000 Serum Booster","description":"\u003cp\u003e\u003cstrong\u003eMatrixyl 3000 Serum Booster is the raw peptide complex, undiluted, in a blue glass dropper. You blend it into your own base at 3 to 8 percent. Nothing is added to stretch it and nothing is hidden — the full INCI is printed below.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis is a formulation ingredient, not a finished serum. Do not apply it directly to skin.\u003c\/p\u003e\n\u003ch2\u003eWhat is in the bottle\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eINCI:\u003c\/strong\u003e Glycerin, Aqua (Water), Butylene Glycol, Carbomer, Polysorbate 20, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7\u003c\/p\u003e\n\u003cp\u003eThat is the complete list. Palmitoyl Tripeptide-1 was called Palmitoyl Oligopeptide until the INCI name changed in 2016 — if you see the old name on another label, it is the same thing.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePalmitoyl Tripeptide-1\u003c\/strong\u003e (pal-GHK) — associated with the look of firmer, better-supported skin\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePalmitoyl Tetrapeptide-7\u003c\/strong\u003e (pal-GQPR) — associated with skin that looks calmer and more even\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWater-soluble. Opaque gel. Fragrance-free, paraben-free. Made in the USA.\u003c\/p\u003e\n\u003ch2\u003eHow much to add\u003c\/h2\u003e\n\u003cp\u003eCount the drops. It is the quickest way to do this at home and it is how most people blend our boosters. Grams are there too, for anyone who wants to reproduce a formula exactly or scale a batch up.\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eConcentration\u003c\/th\u003e\n\u003cth\u003eInto 1 oz of base\u003c\/th\u003e\n\u003cth\u003eInto 2 oz of base\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003e3%\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e27 drops · 0.9 g\u003c\/td\u003e\n\u003ctd\u003e54 drops · 1.8 g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003e5%\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e45 drops · 1.5 g\u003c\/td\u003e\n\u003ctd\u003e90 drops · 3.0 g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003e8%\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e72 drops · 2.4 g\u003c\/td\u003e\n\u003ctd\u003e144 drops · 4.8 g\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eAbove 8 percent you are mostly adding glycerin and water to your base, and thinning everything else in it. Stay in the range.\u003c\/p\u003e\n\u003cp\u003eWorking with a different base size? The \u003ca href=\"\/pages\/product-instructions-for-serum-boosters\"\u003eserum booster conversion chart\u003c\/a\u003e has a calculator, plus the rates for every active we sell.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eChoose a water-based serum, gel, lotion, or cream. \u003ca href=\"\/products\/hyaluronic-acid-serum\"\u003eHyaluronic acid serum\u003c\/a\u003e is the usual pick — it mixes cleanly and carries well.\u003c\/li\u003e\n\u003cli\u003eAdd the drops for the percentage you want.\u003c\/li\u003e\n\u003cli\u003eCap and shake well.\u003c\/li\u003e\n\u003cli\u003eRefrigerate. The blue glass blocks light; the cold keeps the blend stable.\u003c\/li\u003e\n\u003cli\u003eApply the finished blend to a clean, dry face and neck, morning and night. Moisturiser over the top, sunscreen in the morning.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eSuitable for serums, moisturizers, lotions, and eye creams. Not suitable for oil-only blends — Matrixyl 3000 is water-soluble and will not incorporate into jojoba, argan, coconut, or rose hip.\u003c\/p\u003e\n\u003ch2\u003eWhy buy the raw material instead of a finished serum\u003c\/h2\u003e\n\u003cp\u003eTwo reasons.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eYou control the number.\u003c\/strong\u003e Most finished products naming this ingredient will not tell you how much is in them. When you blend it yourself, you know — because you counted it in.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIt goes further.\u003c\/strong\u003e One 15 ml bottle blends about ten 1 oz serums at 5 percent. You are buying the active, not the water it usually comes packaged in.\u003c\/p\u003e\n\u003cp\u003eIf you would rather not mix anything, the \u003ca href=\"\/products\/matrixyl-collagen-booster-serum\"\u003e20% Matrixyl Collagen Serum\u003c\/a\u003e is already blended and the percentage is on the label.\u003c\/p\u003e\n\u003ch2\u003eBlending with other peptides\u003c\/h2\u003e\n\u003cp\u003eMatrixyl 3000 is compatible with vitamin C, niacinamide, hyaluronic acid, \u003ca href=\"\/products\/syn-ake\"\u003eSyn-Ake\u003c\/a\u003e, Argireline, copper peptide, and \u003ca href=\"\/products\/matrixyl-synthe-6-wrinkle-firming-filler\"\u003eMatrixyl Synthe-6\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eA common pairing: Matrixyl 3000 for the look of firmness across the whole face, Matrixyl Synthe-6 on the specific lines. Apply two minutes apart so each absorbs.\u003c\/p\u003e\n\u003cp\u003eNew to blending? Start with the \u003ca href=\"\/collections\/matrixyl\"\u003efull Matrixyl 3000 guide\u003c\/a\u003e — usage rates, comparisons, and the questions we get asked most.\u003c\/p\u003e\n\u003ch2\u003eStorage and shelf life\u003c\/h2\u003e\n\u003cp\u003eRefrigerate on arrival. 12 months from opening — the label carries an open-jar symbol with an 12 in it. Store the blended product at room temperature.\u003c\/p\u003e\n\u003ch2\u003eA note from the formulator\u003c\/h2\u003e\n\u003cp\u003eI have been formulating with this ingredient for most of my twenty years at the bench, and I sell it raw for the same reason I put percentages on every label: you should be able to find out what is in what you are using.\u003c\/p\u003e\n\u003cp\u003eBlend it at 8 percent into a hyaluronic acid base and you have made a better serum than most of what is on the shelf, for a fraction of what it costs — and you will know exactly what is in it, because you put it there.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e— Kari Thomas, Founder and Cosmetic Formulator\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eFor external use only. Cosmetic grade. Do not apply undiluted to skin. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your professional skin care provider.\u003c\/em\u003e\u003c\/p\u003e","brand":"Skin Perfection","offers":[{"title":".5 ounce","offer_id":42915144663280,"sku":"SPO-Matrixyl3000-.5oz","price":29.95,"currency_code":"USD","in_stock":true},{"title":"4 - ounce","offer_id":44069980766448,"sku":"SPO-Matrixyl3000-4oz","price":149.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0069\/7719\/1993\/files\/matrixyl-3000-palmitoyl-peptides.jpg?v=1762819143"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0069\/7719\/1993\/collections\/25cf5d651726d2bcbf58fe9f148e508f_52c4e18a-7281-4283-8250-01f734e5ccb5-1310988.jpg?v=1769948807","url":"https:\/\/nituralorganicskincare.com\/collections\/matrixyl.oembed","provider":"Skin Perfection Natural and Organic Skin Care","version":"1.0","type":"link"}